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to rats there are a few simple rules to observe when working in the animal facility. It is important to wear good protective clothing — gown or boilersuit, hat and gloves — and adequate respiratory protection at all times. Masks should be changed regularly as their. ef?ciency becomes impaired and damaged gloves should be
techniques and guidelines for safe injection volumes, sites of administration, preparation of sites, injec- tion techniques etc. will be described of laboratory rats which are, beside mice, the most frequently used animals in experimental studies. Nearly every route of administration can be per- formed relatively painlessly if
For example, “Crl:WI(Han) rat” indicates the origin and source of this outbred rat, compared to the term 'Wistar Han rat,” which does not indicate the source of the In 2003, the International Committee on Standardized Genetic Nomenclature for Mice and the Rat Genome and Nomenclature Committee unified the rules and
Standardization of the genetics, sanitary status and environment of the species Mus musculus (mice), Rattus norvegicus (rats), Oryctolagus cuniculus (rabbits) and Sus . A comparison of the routines at four different animal houses that bred Sprague-Dawley and Wistar rats, investigating the parameters of frequency of cage
experiments followed the “Principles of Laboratory Animal Care” and refer to the Guidelines for the Care and Use of Mammals in. Neuroscience and Behavioral Research (NRC 2003.) Animals and Housing Conditions. Subjects were 108 male rats (HsdCpb:WU; Wistar Unilever, Harlan Laboratories BV, Horst, NL), 6 weeks
Oct 19, 2002 requirements of experimental procedures will preclude meeting some species-specific needs (Clause 4.4.19). Housing in these situations should still meet the physiological and psychological needs of rats as closely as possible. 2.2.1 As a guide, based on the information from Scharmann 1991,
The albinos of the Norway rat were first domesticated in Europe in the early 19th century and came into use as experimental animals shortly thereafter size, and preweaning mortality were evident among major inbred strains such as Brown Norway, Fischer 344, Osborne-Mendel, Sprague-Dawley, and Wistar (Table 2-1).
Animal testing regulations are laws or guidelines that permit and control the use of non-human animals for scientific experimentation. They vary greatly around the world, but most governments aim to control the number of times individual animals may be used; the overall numbers used; and the degree of pain that may be
Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Kilkenny C, Browne W, . STZ can be administered as multiple low doses over 5 days to induce insulitis in mice (Like and Rossini, 1976; Wang and Gleichmann, 1998) or rats (Lukic et al., 1998). . BB rats were derived from outbred Wistar rats.
Genetic Selection: Rats, like mice are available in various more or less genetically defined varieties, but these are much The two most common stocks of rats encountered are the so-called Wistar and Sprague-Dawley. . justifiable on the basis of special research and breeding requirements. Every effort should be made to
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